San Luis Obispo is a city in the U.S. state of California, located 190 miles north of Los Angeles in Southern California's Central Coast region. The population was 45,119 at the 2010 census. The population of San Luis Obispo County was 269,637 in 2010.
Founded in 1772 by Spanish Franciscan Junípero Serra, San Luis Obispo is one of California's oldest European-founded communities. Serra's original mission was named after the 13th-century saint and bishop Louis of Toulouse. The city, locally referred to as San Luis, SLO, or SLO Town is the county seat of San Luis Obispo County and is adjacent to California Polytechnic State University.